1.Cornea: The typical change is the corneal posterior embryonic ring, that is, Schwalbe’s line proliferates prominently and anteriorly, from the front of the cornea or with a slit-lamp microscope, there is a white line or ring at the back of the cornea close to the corneal limbus, which is confined to a certain part (the most common is the temporal side) or presented in a 360 °, the posterior embryonic ring of the cornea can be seen in 8%～15% of the general population, and there are a small number of patients who do not have a posterior embryonic ring of the cornea, but have the present syndrome. There are a few patients who do not have posterior corneal embryonic ring but have other ocular and systemic abnormalities of this syndrome, the patients are transparent in other parts of the cornea except peripheral corneal changes, occasionally there are large corneas or small corneas, and a few patients can see congenital clouding of the central part of the cornea, such as the patients who have suffered from glaucoma for a long time, and they are older, especially those who have had inner eye surgery, the number of corneal endothelial cells, the morphology and the size of corneal endothelial cells may be mildly to moderately changed. 2.Iris corneal angle: With iridocorneal angle examination, the typical prominent Schwalbe line can be seen, and there are strips from the peripheral part of the iris across the atrial angle attached to it, the color and texture of the strips are similar to the iris tissues, with varying thicknesses, and some of them are broken, one end is attached to the cornea and the other end is attached to the iris, and there can be one to two or several strips of tissues in each quadrant, and in some cases, the entire peripheral trabecular meshwork is covered by the tissues. In some cases, the entire peripheral trabecular meshwork is covered by tissue bands, and it is inconclusive whether there is a direct relationship between the number of such tissue bands and the obstruction of atrial water exudate channels. In the slightly distal part of the tissue bands, the angle of the atrium is open, and the trabecular meshwork can be seen, but the scleral prominence cannot be seen because of the high peripheral iris attachment and the iris terminates in the posterior part of the trabecular meshwork. 3, Iris: In addition to the abnormalities of the peripheral iris, the iris is normal in some eyes in A-R syndrome (Axenfeld’s anomaly in the traditional classification), and the defects of the iris in other cases range from mild stromal thinning to obvious iris atrophy with hole formation, pupillary ectasia, and ectropion of pigmented membranes (Rieger’s anomaly in the traditional classification), etc. When there is pupillary ectasia, under slit-lamp microscope When there is pupillary ectasia, under slit-lamp microscope, the pupil can be seen to be displaced to an obvious peripheral tissue band, and iris atrophy and hole formation are in the quadrant far away from the direction of pupillary ectasia. In a few patients, the changes of iris ectasia will progress gradually, including pupillary ectasia or deformation, iris thinning or cleft formation, and thickening of the peripheral iris tissue bands. 4, glaucoma: about half of the patients with A-R syndrome develop glaucoma, which can be shown in infancy, but is more common in children or young people, and mostly occurs in patients with iris tissue strips, but whether the number of tissue strips is positively proportional to the occurrence of glaucoma has not yet been confirmed.