High HDL generally does not require treatment, but if it is caused by a disease, medication and other treatments are needed to address the primary cause. The function of HDL is to transport cholesterol from peripheral tissues to the liver for recirculation or excretion in the form of bile acids, thus preventing the occurrence of atherosclerotic diseases. The normal reference range is 1.03-2.07 mmol/L. High HDL is usually normal and does not require intervention. In some diseases such as chronic hepatitis and primary biliary cholangitis, an increase in HDL cholesterol may also occur, which can often be normalized after pharmacological or surgical management of the primary disease. Patients with high HDL due to primary disease are advised to seek medical attention when necessary and to follow the doctor’s instructions.