Blood creatinine rises to 2000μmol/L can be treated with active etiologic treatment and renal replacement therapy and so on. For patients with chronic renal failure, blood creatinine 2000μmol/L belongs to the uremic stage, and patients need renal replacement therapy. Renal replacement therapy includes hemodialysis, peritoneal dialysis and kidney transplantation. In addition, anti-anemia, acid correction and other treatments need to be given according to the patient’s complications. For patients with acute renal failure, blood creatinine 2000μmol/L needs active etiologic treatment, correcting reversible factors leading to renal failure, actively preventing and controlling complications, and timely renal replacement therapy. If the patient found that the blood creatinine 2000μmol / L, it is recommended to go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.