Niuhuang Detoxification Tablets are composed of artificial niuhuang, xionghuang, gypsum, rhubarb, scutellaria, orris, ice chips, and licorice. Adverse reactions include: 1, digestive system: diarrhea, abdominal pain, nausea, vomiting, dry mouth, stomach discomfort, etc.; there are case reports of abnormal liver biochemical indexes and gastrointestinal bleeding. 2. Skin and its accessories: rash, pruritus, facial edema, etc. There are case reports of severe drug rash (e.g. Stevens-Johnson syndrome, maculopapular epidermal necrolysis-relaxing drug rash). Arsenic toxicity such as skin roughness, thickening and pigmentation may occur with overdose or long-term use. 3, mental nervous system: dizziness, headache, drowsiness, insomnia, etc. 4, immune system: allergic-like reactions, anaphylaxis, etc. 5, cardiovascular system: palpitations, etc. 6.Respiratory system: difficulty in breathing, chest tightness, etc. 7.Urological system: there are case reports of hematuria, acute kidney injury, etc. In addition, there are reports of cases of arsenic poisoning caused by long-term use. This product contains andrographis, should not be taken in excessive doses or for a long period of time, and should not be taken at the same time with other drugs containing andrographis. Excessive or long-term use may lead to arsenic poisoning manifestations such as skin roughness, thickening and pigmentation. It should be used with caution for patients with severe liver injury, acute and chronic kidney disease. It is prohibited for pregnant women, nursing mothers, infants and children.