There are several possibilities for blisters on the thumb: 1. Daniostasis: mainly bacterial infection after the hand has been pierced by a fish or bone spur. In the treatment can take oral amoxicillin capsules, or roxithromycin capsules, topical mupirocin ointment, and can be wet-applied ralph lauren polo solution 2 times / day for treatment; 2, herpes simplex: mainly due to herpes simplex virus infection caused by clusters of set distribution of blisters, accompanied by a certain stinging pain, you can take oral vaxilovir hydrochloride particles 0.3 grams, 2 times / day, topical acyclovir ointment to For treatment; 3, eczema: mainly due to allergic reactions caused by contact with paint or dyes, etc.. In the treatment can be oral loratadine capsules, topical dinaide cream treatment.