Acid rising from the stomach in the middle of the night may be caused by gastroesophageal reflux, chronic gastritis, peptic ulcer, etc. It can be treated by adjusting lifestyle, medications such as omeprazole, domperidone, and surgery. 1. Gastroesophageal reflux: due to the weakening of the esophageal anti-reflux defense mechanism, patients experience heartburn and reflux symptoms, which can be treated by changing the lifestyle and dietary habits, following the doctor’s prescription of medication, such as domperidone, cimetidine, omeprazole, etc., and surgery if necessary. 2. Chronic gastritis: caused by Helicobacter pylori infection, diet and environment, autoimmune and other factors, there will be hidden pain in the upper abdomen, acid reflux and other symptoms, follow the doctor’s prescription medication, such as cimetidine, lansoprazole, vitamin B12 and so on. 3. Peptic ulcer: caused by Helicobacter pylori infection, drugs and other factors, belching (hiccups), acid reflux, burning pain and other symptoms, can be taken in accordance with the doctor’s instructions, such as clarithromycin, amoxicillin, omeprazole, bismuth potassium citrate and other medication, to protect the gastric mucosa medication, aluminum thioglycollate, aluminum hydroxide, etc., by the ineffectiveness of the medical treatment can be taken to the surgical treatment. It is recommended that patients appear in the middle of the night in the stomach with acid, timely go to the hospital for treatment.