Walking like stepping on cotton, a somatosensory disorder, may be subacute combined degeneration of the spinal cord. The disease is a neurodegenerative disorder caused by vitamin B12 deficiency, and the lesions mainly involve the posterior and lateral cords of the spinal cord as well as the peripheral nerves. The majority of patients develop the disease after middle age, with an insidious onset of the disease, and the disease progresses gradually and slowly, and a history of anemia, diarrhea, and tongue inflammation may precede the appearance of neurological symptoms. In the early stage, patients may have weakness, stiffness, clumsiness, unsteady walking, and a feeling of stepping on cotton. Subsequently, there may be sensory abnormalities in the ends of the fingers and toes, which may be characterized by symmetric tingling, numbness, and burning sensations, as well as vibratory and positional sensory disturbances in both lower limbs. A few patients may have glove sock-like hyperalgesia, and some patients may also have psychiatric symptoms, which may manifest as irritability, depression, hallucinations, and cognitive dysfunction, and the treatment of this disease is mainly early high-dose application of vitamin B12.