Nowadays, the incidence of cranial defects is really high. In neurosurgery, there are many patients with cranial defects due to such and such accidental factors, who seem to be no different from normal people, but if they are not treated and handled in time, it will lead to more serious injuries in the long run. As a result, cranial defects should not be taken care of at all. For patients with cranial defects of more than 3cm in diameter and no contraindications to surgery, it is necessary to go to the hospital in time to have cranial bone repair surgery. In this way, the closure and integrity of the cranial cavity can be better restored, the stability of intracranial pressure and intracranial environment can be restored, so as to alleviate the syndrome of cranial defects. However, in cranial bone repair surgery, the repair material is a very important factor, patients should not be careless. At present, the main medical use of titanium mesh material and polyether ether ketone peek material, exactly neurosurgery cranial bone repair, polyether ether ketone and titanium alloy which is more suitable for it? Many patients are entangled, in fact, as long as a careful comparison will know. First of all, titanium mesh material, although it is much more advanced than the early materials, but there are still some shortcomings, for example, some patients in the postoperative period are infected, the outside world of the hot and cold environment is sensitive to discomfort, the patient’s scalp has a cutting pain, the impact of the postoperative medical examination, there is a risk of exposure of the material and so on, from these visible titanium mesh material is not too ideal. Let’s talk about peek material, which is a very advanced polymer biomaterials, it is hardness, stability, thermal insulation, tissue compatibility and other aspects of the performance is very good, it makes up for the various shortcomings of the titanium mesh material, postoperative repair effect is very good, and has become the new trend of the current cranial bone repair materials.