Three-year-old baby night fever 38.8 ℃ twice can be seen in respiratory diseases, gastrointestinal diseases or urinary tract diseases, etc., the treatment needs to be decided according to the cause, such as urinary tract infections need to drink more water, anti-infective treatment. 1. Respiratory diseases: such as acute suppurative tonsillitis, the above phenomenon can occur clinically, often accompanied by sore throat, examination of the tonsils can be seen enlarged and purulent secretions, the need to use amoxicillin and other antibacterial drugs anti-infective treatment, the course of the disease can be used to rationalize the use of ibuprofen antipyretic. 2. Digestive tract diseases: such as acute appendicitis, in the early stage of the disease can appear the above phenomena, often accompanied by abdominal pain, with the progression of the disease, there may be frequent fever, abdominal pain aggravated, need to actively consult the doctor, the use of cefotaxime and other drugs to fight infection. 3. Urological diseases: such as urinary tract infections, clinical night fever, accompanied by urinary frequency, urinary urgency and other symptoms, some of the baby urinary tract irritation signs are not typical, the treatment needs to be actively anti-infective, such as the use of cefaclor and so on. 4. Other: such as acute leukemia, the disease fever type is variable, can appear above fever, can be accompanied by lymph nodes, liver and spleen enlargement, bone marrow aspiration examination can assist in the diagnosis, the treatment requires the use of methotrexate and other drugs for chemotherapy or hematopoietic stem cell transplantation and other treatments. The above drugs need to be used under the guidance of a physician. Three-year-old baby night fever 38.8 ℃ twice may also have other conditions, it is recommended to actively consult a specialist physician to assess the treatment.