Patients with elevated bilirubin after treatment with Febuxostat need to further improve other liver function tests and decide whether to stop the drug depending on the results. Febuxostat is a uric acid-lowering drug mainly metabolized by the liver, and its common adverse effects include liver function abnormalities, nausea, and arthralgia. Patients with elevated bilirubin after treatment with Febuxostat should undergo further liver function tests, such as ALT and AST, to find the cause of liver damage. Elevated bilirubin may be related to drug liver damage, fatty liver, alcohol consumption, late night, hemolysis and other reasons. Symptomatic treatment should be based on the cause. It is recommended that patients with elevated bilirubin after taking febuxostat should go to the rheumatology department of regular hospitals for further relevant examinations in order to avoid delaying the condition.