Iodixanol Injection may cause abnormal somatic pain with an incidence of between 10% and 1%, and the presence of pain requires prompt medical attention. Iodixanol Injection is a commonly used clinical contrast agent for cardiovascular, aortic, peripheral arterial, and cerebrovascular angiography. Adverse reactions such as abnormal hot and cold skin sensations, distal limb pain, abdominal discomfort or pain, nausea, vomiting, dyspnea, rash, erythema, urticaria, and other adverse reactions may occur during the use of this drug, but the incidence is low. The occurrence of the above adverse reactions, must immediately stop using the drug, usually in the drug metabolism after the symptoms can be relieved, if the emergence of respiratory distress and other serious adverse reactions, the need for resuscitation. The drug is contraindicated in cases of hyperthyroidism, drug allergy, etc. Intrathecal injection is prohibited. The drug needs to be discontinued for at least one day after use during breastfeeding, and caution is recommended during pregnancy. Iodixanol injection needs to be used under the guidance of a clinician.