Itchy skin as soon as you go to bed at night may be associated with urticaria, scabies, chronic simple moss, atopic dermatitis, etc. After diagnosis, it can be improved by general treatment and medication, etc. 1. Urticaria (1) General treatment: it may be related to allergy to bedding, cold air stimulation, etc., and should be replaced with cotton sheets and covers in a timely manner to keep warm. (2) Medication: If the itching is severe or persists without relief, anti-allergy medication such as diclofenac tadalafil can be taken orally. 2. Scabies (1) General treatment: Scabies will appear pimples, especially at night there will be intense itching. Scabies is highly contagious, change of clothes, bedding, etc. need to be disinfected, and patients should sleep separately from family members during treatment to prevent infection. (2) Drug treatment: topical drugs such as Lindane cream; if the itching is severe, drugs such as loratadine can also be applied. 3. Chronic simple moss (1) General treatment: the disease will become more and more itchy, so usually avoid scratching, the use of irritating skin care products; daily to reduce mental stress. (2) Medication: Loratadine or topical glucocorticoid cream can be taken. 4. Atopic dermatitis (1) General treatment: try to wear cotton loose clothing; avoid scratching, drinking alcohol and spicy food; pay attention to good skin moisturizing. (2) Drug treatment: glucocorticoid is the first-line drug for treatment, when severe itching, you can also take loratadine and other drugs to relieve. Itchy skin at night, there may be other reasons, it is recommended to go to the hospital, a clear diagnosis and follow the doctor’s instructions for treatment, do not self-medication.