Hepatitis B immunoglobulin is like a warrior, specializing in killing the hepatitis B virus, which is not present in the body of the child at birth, and is injected into the body as soon as the child is born, so that the child immediately has the ability to kill the hepatitis B virus, so that he or she is free from being infected by the hepatitis B virus, which is passive immunity. Hepatitis B vaccine can stimulate the body itself to continuously produce protective antibodies, generally about 1 month can produce, but the amount is relatively small, with the passage of time, the concentration of protective antibodies is getting higher and higher, and ultimately reaches more than 10-100mIU/ml, the formation of immunity against the hepatitis B virus, once formed, the protective force can last for at least 10-15 years, or even lifelong, this is called active immunization. Combined immunization of newborns born to hepatitis B pregnant women can block more than 95% of vertical transmission from mother to child, and since this method has been popularized in the past 30 years, the incidence of hepatitis B in China has decreased dramatically. Although the 2 drugs, as if anywhere can buy, and, just a health care worker can complete the injection operation, but, its specific application is very delicate, with good and bad, blocking effect has obvious differences, think this does not need too much explanation, we will understand. So, exactly how to do it? As long as the mother is positive for any of HBV DNA, HBsAg, or HBeAg, after the child is born and after flushing the amniotic fluid, the mother’s blood, and vaginal secretions, venous blood will be drawn and checked for HBsAg and HBV DNA to determine whether to administer another 200 U of hepatitis B immune globulin 2 weeks later (instead of checking for HBsAg and HBV DNA in the umbilical cord blood, which is something that needs to be pointed out specifically). Immediately administer 200 IU of Hepatitis B immunoglobulin in one triceps muscle, along with 1 dose of Hepatitis B vaccine in the other triceps muscle. Because the child has no resistance to the hepatitis B virus at birth, the longer the administration of exogenous protective antibodies is delayed, the greater the chance that the child will be exposed to the hepatitis B virus attacking the liver, the guidelines require that the injection be given within 12 hours of birth – in fact, the earlier the better: our hospital has specially remodeled the delivery room, nursery, and bathing room for this purpose, and has optimized the Our hospital has remodeled the delivery room, the nursery, the bath and optimized the procedure, so that injections can never be given more than 2 hours after birth. At 1 month and 6 months of age, one dose of hepatitis B vaccine is injected, completing the routine active immunization. If HBsAb is more than 100mIU/ml at 7 months of age, the body has produced sufficient immunity and active immunization is successful; if it is less than 10mIU/ml, it means that the body does not have sufficient immunity against hepatitis B virus, and it is necessary to strengthen the injection of hepatitis B vaccine again, and it is generally necessary to inject hepatitis B vaccine again in accordance with the program of 0,1,6, and follow up accordingly; if HBsAb concentration is between 10 and 100mIU/ml, it means that the body is not sufficiently immune against hepatitis B virus, so it is necessary to reinforce the injection of hepatitis B vaccine again. If the HBsAb concentration is between 10-100mIU/ml, it is recommended to take a booster injection of hepatitis B vaccine for safety reasons. Because the half-life of hepatitis B immunoglobulin is 25 days, if the newborn’s venous blood is positive for HBsAg and HBV DNA, it is necessary to give the child a booster injection of 200IU of hepatitis B immunoglobulin 2 weeks after birth; after 2 weeks of reexamination, if the HBsAg is still positive and the HBV DNA decreases significantly, then give the child another booster injection of 200IU of hepatitis B immunoglobulin in order to strengthen the passive immunization. If HBV DNA and HBsAg are negative, then the mother-to-child blockade is successful. If HBV DNA and umbilical cord blood concentration do not decrease significantly or continue to rise, it is predicted that the child is likely to be infected, and it is not meaningful to inject hepatitis B immunoglobulin again, and the possibility of successful mother-infant blockade is very small, and it is necessary to repeat the examination at 7 months of age, and if there is a significant decrease in HBcAb, and a significant increase in HBsAb (preferably more than 100 mIU/ml), and the HBV DNA has turned negative, then mother-infant blockade is successful. If HBcAb drops significantly, HBsAb rises significantly (preferably above 100 mIU/ml) and HBV DNA becomes negative, then mother-to-child blockade is successful. If the HBV DNA at this time is more than 4 times 10, it can be declared that the mother-to-child interruption has failed. If the HBV DNA is less than 3 times 10 at this point in time, you can wait until the 18th month of life for review, and a few children will also become negative. If the HBsAg also becomes negative at the same time, then the mother-to-child interruption is confirmed to have been successful; otherwise, it is clearly declared that the mother-to-child interruption has failed.