Ling usually has vague stomach pains and rotten stools, with some mucus stools intermittently. When she saw a recent news report: the lively and lovely Chinese girl has been suffering from a strange disease since she was young and needs to take an imported drug to control her condition, however, the drug is not available in the market now. The mother turned to the media to find the medication for the young girl’s relapse. Upon learning about it, she realized that Hua’s daughter was suffering from Crohn’s disease. In contrast, Xiao Ling suspected that she also suffered from this strange disease, so she took the report to the hospital and asked nervously as soon as she entered the consultation room, “Professor, do I also have this strange disease?” After a detailed medical history and physical examination, the doctor suggested her to have a routine stool examination and colonoscopy. A few days later, Xiao Ling came back to see the doctor again with the report card, still repeating the same questions she had last time. The doctor told her: You don’t have this disease. But Xiaoling asked skeptically, “Professor, what is this strange disease? Is it related to having heredity?” The professor explained: Crohn’s disease is a more common gastrointestinal disease, and people think it is a strange disease because of its strange name, which Chinese people are not used to. Crohn (Crohn) is a foreigner, the disease was first described by him in 1932 and then officially named Crohn’s disease internationally in 1973, which used to be translated as clone disease in China. It is a chronic idiopathic granulomatous inflammatory disease of the gastrointestinal tract whose pathogenesis is still not fully understood. It is currently believed to be an intestine-specific immune abnormal disease that occurs on the basis of genetic susceptibility and with the participation of environmental factors, and the lesions can involve the entire gastrointestinal tract, but are mostly seen in the terminal segment of the small intestine and adjacent colon, which is collectively referred to as inflammatory bowel disease with ulcerative colitis. Recent studies have concluded that Crohn’s disease is a polygenic-related disease and that people who carry the NOD2 or CARD15 gene, called CARD15, are susceptible to the disease with a degree of heritability. Xiao Ling still asked uneasily, “My case is similar to Hua’s. What will happen to my body when I have this disease? How can I be diagnosed? How can Crohn’s disease be distinguished from ulcerative colitis?” Professor said: “Crohn’s disease mainly manifests as vague pain in the right lower abdomen or around the navel, rotten stools, usually without obvious purulent stools, abdominal masses, fistula formation and intestinal obstruction, and can be accompanied by systemic manifestations such as fever and malnutrition, as well as extra-intestinal manifestations such as joint, skin, eye, oral mucosa, liver and biliary tract lesions. The diagnosis is mainly based on clinical manifestations, barium X-ray, gastrointestinal endoscopic manifestations and the results of microscopic tissue biopsy, and the diagnosis can be made only after excluding intestinal tuberculosis, intestinal mucosa-associated lymphoma, ulcerative colitis, leukoaraiosis, atopic infectious enteropathy, intestinal cancer, radiation enteropathy, ischemic enteropathy, etc. However, a relatively simple screening test, like yours, a stool routine and gastroscopy, if completely normal, can basically rule out the diagnosis of the disease. The common international diagnostic points are: segmental lesions of the gastrointestinal tract, pavement-like changes or longitudinal ulcers, inflammatory changes in the entire intestinal wall, fistulae and anal lesions, and pathological findings of non-caseating granulomas. In contrast, ulcerative colitis is mainly in the rectum and can progress to the upper colon as a continuous inflammatory lesion, mainly involving the mucosal and submucosal layers of the colon. The clinical manifestations are similar to those of Crohn’s disease, but mucus and blood in the stool are more common and extraintestinal manifestations are less common. The main manifestations on colonoscopy are congestion, edema, erosion, shallow ulcers and inflammatory polyp formation in the colonic mucosa. found to respond better to treatment with drugs and a better prognosis.” Xiao Ling asked uneasily, “With this disease, will it be like the Chinese woman, who can’t even buy medicine in China?” The professor further explained, “No, there are several drugs for the treatment of Crohn’s disease, mainly aminosalicylates (mainly salicylic acid and 5-aminosalicylic acid), glucocorticoids (such as prednisone, dexamethasone, methylprednisone, budesonide, etc.) and immunosuppressive drugs (such as azathioprine, mercaptopurine, methotrexate, cyclomycin, etc.), which are commonly used and The most effective is the glucocorticoid azathioprine. Adjunctive medications include certain antibiotics (e.g., metronidazole, quinolones, etc.), intestinal microecological agents, and intestinal nutritional agents. If the above treatment is still ineffective, anti-tumor necrosis factor monoclonal antibody (Infliximab) can be used to treat the disease, but it is expensive and not completely curable in all patients, and some patients can also be treated with stem cell transplantation. Finally, surgical resection of the diseased intestinal segment is an option, but it is mainly for the complications of Crohn’s disease, and the indications should be chosen very carefully and strictly, because the recurrence rate and complications are still high after surgery. In conclusion, the treatment of Crohn’s disease should follow the principle of individualization, and different drugs should be selected for treatment according to different lesion sites, different periods of time, and different economic status. If the disease is diagnosed and treated early, it can have good results or can be controlled for a long time, but at a later stage, it is very difficult to deal with. Once the disease is suspected, a gastroenterologist should be consulted as soon as possible to confirm the diagnosis, and cooperate with the doctor to carry out a long course of standardized treatment, and long-term clinical and endoscopic follow-up and monitoring of adverse drug reactions to understand the changes in the disease and the effectiveness of treatment, and timely adjustment of the treatment plan. Except for very few mild patients, who can be cured or in long-term remission naturally or after a certain period of drug treatment, most patients often have recurrent attacks and deteriorate continuously, therefore, some patients need long-term drug maintenance treatment, and the drugs for maintenance treatment can be 5-aminosalicylic acid, azathioprine, mercaptopurine, metronidazole, etc. Regular endoscopic follow-up not only guides treatment, but also detects whether the lesion has deteriorated or become cancerous.” Finally, Xiao Ling asked, “Professor, what kind of disease do I have? Will I develop Crohn’s disease later?” The professor said reassuringly, “You have irritable bowel syndrome, a functional gastrointestinal disorder, and there is no evidence that it will develop into Crohn’s disease or ulcerative colitis.” Xiao Ling was happy to hear this and left the clinic. Tips:Our hospital has started the clinical work of biological agent class gram and bone marrow mesenchymal stem cell treatment for Crohn’s disease since 2009, patients are welcome to visit our hospital.