When retinol binding protein exceeds 56mg/L in men and 57.9mg/L in women, it is on the high side, but the severity needs to be determined on a case-by-case basis. Retinol-binding protein is widely distributed in blood, cerebrospinal fluid, urine and other body fluids, and plays an important role in human function. Under normal circumstances, retinol-binding protein can be filtered in the glomerulus and appear in primary urine, which is an indicator for clinical monitoring of renal tubular function damage and early damage to liver function. Lower retinol binding protein can be seen in trauma, hyperthyroidism, vitamin A deficiency, etc. Elevated retinol binding protein can be seen in gouty nephropathy, obstructive nephropathy, fatty liver, systemic lupus erythematosus and so on. High retinol binding protein should be combined with a series of indicators such as creatinine, micro-protein, liver enzymes to assess the severity of the disease. When the retinol is high, it is recommended to do a full range of tests to identify the cause of the disease and then carry out targeted treatment.