The growth of granulation between toenail and flesh may be caused by onychomycosis, benign tumors, granulomatous hyperplasia and other reasons. 1. Inguinitis: Inguinitis is a kind of inflammation that involves the surrounding skin folds, which is mainly caused by purulent cocci and yeast. It can be caused by stimulated invasion of moist nail grooves, which can cause long granulation in the middle of toenails and flesh, and can be treated with mupirocin ointment, clobetasol propionate ointment, clarithromycin and so on under the guidance of a doctor. 2. Congenital benign tumors: mainly due to the remnants of embryonic angiogenesis, the active endothelial germ of the cells, will invade the adjacent tissues, thus connecting to the rest of the blood vessels and the formation of hemangiomas. 3. Granulomatous hyperplasia: it is a symptom caused by local tissue irritation, which can be treated by local tissue disinfection care. It is recommended to go to the hospital for examination, identify the cause of the disease, and then timely symptomatic treatment under the guidance of the doctor.