There are many hazards of antibiotic abuse, which can cause imbalance of flora in the body, leading to fungal infection and secondary infection. Therefore, the preventive countermeasures of antibiotic abuse should be taken to eliminate antibiotic resistance gradually by taking antibiotics orally instead of injecting them, using antibiotics singly instead of in combination, and using them with a doctor’s prescription. When antibiotics can not be used in general, antibiotic abuse should be avoided as much as possible. When oral antibiotics can be used, injections or needles are not necessary; when antibiotic treatment is needed, it is better not to use combination therapy; when combination therapy is needed, it is better to try to use two combinations of antibiotics as much as possible instead of choosing three combinations of antibiotics or four combinations of antibiotics. Antibiotics can only treat bacterial infections but cannot prevent them, so it is best not to use antibiotics without a clear cause of the disease. Antibiotics are prescription drugs, and when antibiotics are needed, they should be used under the advice of a doctor, and it is not recommended that the patient use them on his own. Antibiotics abuse, will cause drug resistance, try to be able to single use not combined, can be low level not high level, toxicity of strong cautious use.