Patients with advanced lung cancer do not need chemotherapy all the time, because if a patient with advanced lung cancer is found to have genetic mutation, there happens to be a suitable targeted drug, such a patient can control the lesion without chemotherapy and only take targeted drugs. Patients with lung cancer can undergo chemotherapy if they have good physical strength, but when their physical strength is particularly poor, such as white blood cells below 2000/mL, red blood cells and hemoglobin below 8g/L, platelets below 80,000/L, the patient’s general state is very poor and excitement function is not good, such patients are not recommended to undergo chemotherapy. There are indications and conditions for chemotherapy, and it is not going to be chemotherapy all the time, and appropriate local treatment is necessary. Therefore, lung cancer patients do not always need chemotherapy even at advanced stage, but targeted drugs, immunotherapy, and anti-vascular drug therapy can be applied.