At present, the commonly used wrinkle removal injection is botulinum toxin type A, commonly known as Botox, which is used to treat wrinkles by blocking neuromuscular conduction and inhibiting muscle contraction. Wrinkle removal injection has the advantages of less damage, faster recovery, obvious effect and less side effects. The effect usually starts 3 days after the injection of Botox, and the effect will be fully developed in about 1 week, and the maintenance time of the first injection is about 6 months. The maintenance time of wrinkle removal injection is related to individual reaction, own protection, metabolism and so on, usually can maintain about half a year. The doctor will instruct the patient to take precautions after the injection, such as the injection site should not be exposed to high temperatures (such as excessive sunlight, sunbathing or steam bathing) until the local swelling and redness have subsided, the injection area should not be massaged or cared for within 1 week, and avoid taking antibiotics such as gentamicin. If you follow the doctor’s instructions and avoid irritants, the wrinkle injections can last longer, but if you do not follow the doctor’s instructions, the duration of the wrinkle injections may be shortened. As the body will gradually metabolize the drug, the expression muscle will gradually regain its contraction function, and wrinkles will slowly appear again, then it is necessary to inject Botox again, the second injection time is generally in six months to a year, according to individual circumstances repeat injection.