The cause of acute myelogenous leukemia, or AML, may be related to gene mutation or genetic inheritance, but the exact cause is not completely clear, and may include exposure to hazardous chemicals, radiation exposure, infections, and regression of other types of blood diseases. 1. Many patients with acute myeloid leukemia are associated with fusion gene positivity or gene mutations, such as t(8;21) and FLT3-ITD expression. Prolonged or heavy exposure to harmful chemicals, such as benzene, phenol, and formaldehyde, may increase the likelihood of acquired mutations. 2. Excessive or prolonged exposure to X-rays and γ-rays, such as undergoing radiation therapy and frequent CT scans, may also increase the probability of gene mutation. Moreover, these chemical or physical factors may directly lead to the development of AML. 3. In addition, viral infections such as EBV and cytomegalovirus may also lead to AML. 4. Certain hematologic diseases such as myelodysplastic syndromes and myelofibrosis may regress to AML in the late stages of the disease. Diagnosis and treatment of specific diseases should be made under the supervision of a physician.