Total bile acids greater than 10umol/L in pregnant women are considered abnormal. Pregnant women with total bile acids greater than 10umol/L are considered to have intrahepatic cholestasis of pregnancy, with serum total bile acids in the range of 10-40umol/L considered mild and ≥40umol/L considered severe. Intrahepatic cholestasis in pregnancy occurs mainly in late pregnancy and rarely in mid-pregnancy, and is characterized by otherwise unexplained itching of the skin and high values of bile acids and abnormalities of hepatic function, which mainly endanger the fetus. Cholestasis in pregnancy can cause abnormalities in maternal coagulation leading to postpartum hemorrhage. For the fetus, fetal distress or amniotic fluid meconium contamination can occur due to the toxic effects of bile acids. Increased total bile acids during pregnancy also need to rule out the presence of viral hepatitis and other digestive disorders. Total bile acid is found to be elevated during pregnancy, it is recommended to go to the hospital under the guidance of the doctor to give standardized treatment.