Can sugar substitutes cause insulin resistance?

Sugar substitutes generally do not cause insulin resistance.
Sugar substitutes are low-calorie artificial sweeteners that are used to provide sweetness as well as increase taste. Sugar substitutes, when consumed in moderation, do not cause an increase in blood glucose because blood glucose does not affect insulin secretion, and likewise do not cause insulin resistance.
Artificial sweeteners are metabolized differently in the body due to their different properties. Most of the clinical studies conducted to date have not reported any significant effect or beneficial effect of artificial sweeteners on glycemic control.
But some studies have suggested that eating sugar substitutes may increase diabetes risk.In 2019, a heavyweight study led by Harvard University and involving researchers from Fudan University and Huazhong University of Science and Technology was published.The data, which followed nearly 200,000 people for 26 years, showed that drinking sweetened beverages increased the risk of diabetes regardless of whether they were fat or thin, but that the risk appeared to be greatest for drinking more artificially sweetened beverages.
Therefore, although sugar substitutes do not affect blood sugar, they are not recommended for excessive intake. Diabetic patients need to strictly control the intake of foods with high sugar content in their daily life, and also limit the total calorie intake of each meal to avoid causing excessive fluctuation of blood glucose, which may affect their health. More dietary knowledge can be consulted with a nutritionist, under the guidance of the doctor’s scientific and reasonable consumption.