Patient: Description of the condition (time of onset, main symptoms, hospital visited, etc.): A lump was found in the right breast on September 6, and the result of the puncture examination was breast cancer on September 9, and modified radical right breast surgery was performed on September 13. Pathological findings: 12.5X5CM with pyknotic skin, 2.5X2.5X2.5CM mass 2CM from the nipple, no metastasis in the right axillary lymph (0/9), immunohistochemistry: ER[++],PR[++],CerbB-2[2+],E-cad[+],CK5[-],KI-67[50%+] Three weeks of AC-T regimen has been used. Three times of chemotherapy. Can you give me any treatment advice? If the result is positive, the patient should be treated with Herceptin for 1 year starting from the subsequent T regimen. If the result is negative, oral endocrine medication for 5 years after completion of the AC-T regimen will be sufficient. Patient: What kind of test is FISH? What is the cost? If the result is positive, we have to add Herceptin treatment for 1 year starting from the follow-up T program, is it the so-called targeted therapy? If positive, the follow-up Herceptin is a targeted therapy, which can significantly reduce the recurrence rate.