Itching while running is generally considered to be cholinergic urticaria. This situation is mostly due to their usual seldom exercise exercise, suddenly began to run after the body’s regulatory function can not adapt to the new body condition of the itching symptoms, generally believed to be caused by exercise to raise body temperature, cholinergic nerves release acetylcholine, the role of mast cells, the latter activated after the release of allergic substances caused by. At this point the application of cholinergic antagonists for the treatment of common itching may not even be effective. An effective treatment is to increase the amount of exercise step by step, allowing the body to adapt to the cholinergic changes in the body after exercise. Generally speaking, after a period of gradual exercise adaptation, the situation will be significantly improved or cured. Therefore, when itching while running, you should pay attention to maintain appropriate exercise, avoid sudden large amount of exercise, and gradually increase the amount of exercise. If the symptom of itching while running is serious, or the symptom persists and does not get better, you should go to the hospital in time for treatment.