Recently, laparoscopic hepatic caudate lobe tumor resection was performed in F5D ward of general surgery department of our hospital for a patient with hepatic caudate lobe tumor. The operation went smoothly, and the patient recovered satisfactorily after operation, and was discharged from the hospital on the 5th day after operation with removal of abdominal drainage tube. A 23-year-old female patient was diagnosed with focal nodular hyperplasia of the liver (FNH) when she was admitted to an outside hospital because of “liver metastasis found on examination for more than 40 days”. The patient came to our hospital and was admitted to ward F5D. After detailed preoperative evaluation and preparation by the treatment team, laparoscopic hepatic caudate lobe tumor resection was performed on December 17 under general anesthesia. The operation was performed by Prof. Hu Sanyuan, Dr. Zhan Hanxiang and Dr. Han Haifeng. During the operation, the tumor was found to be located in the caudate lobe of the liver, which was about 5.0×4.0 cm in size, and the tumor was compressing the inferior vena cava and portal vein. The right half of the liver was firstly freed, and the posterior hepatic inferior vena cava was revealed, the third hepatic hilar was dissected, and the short hepatic vein was ligated and cut off. The traffic vessels between the tumor and the inferior vena cava were carefully cut off one by one by using the hemolok clamps and the inferior vena cava was detached from the tumor from the bottom upwards. The tumor was found to grow along the anterior aspect of the inferior vena cava toward the second hepatic hilar, and its location was relatively deep. After incising the lesser omental bursa, the hepatic-duodenal ligament was pulled to the right side to free the tumor, and the trophoblastic blood vessels from the portal vein to the tumor were cut off, and the tumor was completely freed and resected. The operation lasted about 4 hours and the bleeding was about 350 ml. The patient got out of bed on the first day after the operation, recovered intestinal function on the second day, and was discharged from the hospital on the fifth day. Breaking through the “forbidden zone” of liver surgery and minimally invasive tumor removal General Surgery F5D ward completed a case of laparoscopic hepatic caudate lobe tumor resection The caudate lobe of the liver is located deep in the liver, adjacent to the abdominal blood vessels, which was once a “forbidden zone” for liver surgery. With the deeper understanding of the caudate lobe anatomy and the improvement of surgical techniques, the open hepatic caudate lobectomy has been gradually applied and matured, but the operation is still difficult. Laparoscopic hepatic caudate lobe surgery is even more difficult, with few reports at home and abroad, and the tumors are mostly exophytic. Professor Hu Sanyuan led a team to complete a case of laparoscopic caudate lobe resection of exophytic tumor in 2014. In this case, the patient’s tumor was deeply located and compressed the inferior vena cava and portal vein, which made the surgery more difficult. The successful implementation of this case shows that the laparoscopic technology of our hospital is at the leading level in China and fills the gaps in the relevant fields in the province.