Gallbladder stones combined with common bile duct stones is a common surgical disease, which can be diagnosed by ultrasound, CT, MRI or MRCP and other imaging, and routine liver function and blood tests. After the diagnosis is clear, the following three treatment methods are adopted to treat gallbladder stones combined with common bile duct stones: 1. laparoscopic cholecystectomy and common bile duct extraction (LC+LCBDE); 2. open cholecystectomy and common bile duct extraction (OC+OCBDE); 3. laparoscopic cholecystectomy plus transduodenoscopic Oddi sphincter extraction (LC+ ERCP+EST). Which of the above treatment options is the best to adopt? Considering the patient’s condition, the doctor’s own technical level, the hospital’s equipment and facilities, and the current scientific basis, the most suitable treatment plan is chosen. Diagnostic measures: For patients with clinically suspected gallbladder stones combined with common bile duct stones, there is no need to take other diagnostic imaging measures if the diagnosis can be confirmed by ultrasound. If the diagnosis of common bile duct stones cannot be confirmed by ultrasound, the doctor should choose CT or MRI of the upper abdomen according to the patient’s condition and economic situation, and if necessary, magnetic resonance cholangiopancreatography (MRCP) should be taken to confirm the diagnosis. Treatment options: 1. For gallbladder stones complicated with secondary stones in the common bile duct, diameter of the common bile duct > 1.0 cm, and relatively large stones in the common bile duct, laparoscopic cholecystectomy and common bile duct excision for stone extraction (LC+LCBDE) can be performed. 2.For patients with smaller diameter of common bile duct stones and less dilated common bile duct, laparoscopic cholecystectomy with transduodenoscopic Oddi sphincterotomy for stone extraction (LC+ERCP+EST) can be performed, which has the advantage of no long-term drainage with T-tube and short treatment cycle. 3. For those who do not have the conditions for minimally invasive surgery, open cholecystectomy + choledochotomy for stone extraction and T-tube drainage is feasible.