For the treatment of megasplenism, the main clinical practice is surgical removal of the spleen, but there are strict indications for surgical removal of the spleen, which include the following: 1) The patient’s spleen is enlarged significantly, resulting in obvious clinical symptoms of compression, such as abdominal distension, abdominal pain, and difficulty in defecation. 2) The patient’s anemia is more serious, especially if the patient has hemolytic anemia. 3) The patient can undergo splenectomy if there is severe thrombocytopenia or bleeding symptoms, but note that sometimes if the patient’s platelet count is normal or mildly reduced, the spleen may be removed. The spleen needs to be removed to relieve the patient’s clinical symptoms.3. If the patient has severe thrombocytopenia or bleeding symptoms, splenectomy can be carried out. However, it should be noted that sometimes if the patient’s platelet count is normal or mildly reduced, the phenomenon of thrombocytosis will occur after the removal of the spleen, and sometimes even splenic artery thrombosis may occur, which requires postoperative anticoagulation therapy if the spleen is removed.4. If the patient has granulocytopenia and has a history of recurrent infections, he or she can be treated surgically, but it depends on whether the patient’s general condition is good or not.