Headache, fever and vomiting are mainly seen in the following diseases: first, upper respiratory tract infection, upper respiratory tract infection can be manifested in the type of headache, high fever, nausea, vomiting, at this time, routine blood tests can be performed, lymphocytes are found to be increased or reduced, and then antiviral or cold medicine can be given orally after the patient’s symptoms can be relieved. Secondly, if the patient has persistent headache, fever with nausea and vomiting, headache is mainly distension and pain, and some patients also have epilepsy, we should consider that the patient may have intracranial infection caused by increased cranial pressure is related. This is the time to get a cranial MRI scan with enhancement and a lumbar puncture to determine the brain pressure. If the headache, fever and vomiting are caused by intracranial infection, the main treatment is to lower the intracranial pressure or antiviral treatment.