One of the most frightening or embarrassing things in the treatment of chronic kidney disease is the acute exacerbation of renal impairment during the treatment process. According to professional statistics, the incidence of such events is very high, and the clinical term for this phenomenon is chronic kidney disease combined with acute injury. As the cellular workload increases significantly in kidney disease, patients with kidney disease have to undergo frequent drug interventions, such as diuretics, antihypertensives, antibiotics, immunosuppressants, etc., which can easily cause the kidneys to suffer secondary blows. In addition to chronic kidney disease, some other organ diseases (coronary heart disease, cerebrovascular disease, various infections, gastric ulcers) Acute impairment of renal function also occurs frequently during diagnosis and treatment. One study found that post-surgery is a high incidence of acute kidney injury, with nearly one-third of patients after cardiothoracic surgery experiencing acute renal impairment, while trauma, cardiovascular interventions, chemotherapy for tumors, and unexpected events such as earthquakes and traffic accidents are mostly frequently combined with kidney damage. Thus, it seems that acute kidney injury can occur in almost every medical corner of the hospital and must be taken seriously. Acute kidney injury is usually asymptomatic in the early stage, but at a certain stage, oliguria and general discomfort appear, and if there is no early intervention, the condition will deteriorate rapidly and is difficult to reverse. Therefore, both specialists and patients with kidney disease should acquire basic knowledge in this area to avoid the risk of acute kidney injury in the treatment process as much as possible. The following knowledge about acute kidney injury you must grasp 1, sometimes, Chinese medicine prescriptions not only can not cure the disease, may have obvious nephrotoxicity The elderly own organ function physiological decline, liver and kidney detoxification and excretory functions are significantly reduced, even conventional doses of drugs in these people can cause acute kidney damage. The elderly have less muscle tissue and less muscle catabolism, so it is difficult to grasp the amount of medication based on blood creatinine level, and once renal damage occurs, it is also difficult to judge by creatinine level, so the elderly need to be closely monitored after medication. Diabetes is a special group, these diseases are mainly chronic lesions of blood vessels, atherosclerosis is its most basic lesion characteristics, once the renal artery is involved, the kidney blood perfusion itself is in a poor state, any wind (dehydration, severe hypertension, the use of contrast agents, combined with other drugs, etc.) are very likely to cause acute kidney injury. Patients with cirrhosis and heart failure have insufficient effective blood volume in their own bodies, and their kidneys are in a state of chronic ischemia, and regular medication and other triggers (diarrhea, cold, etc.) often lead to renal failure. Therefore, theoretically, the above-mentioned groups of people should use less medication and try to improve the workload of their organs by controlling their diet and changing their lifestyle habits as much as possible, and when they have to use medication, they should learn to focus on the major and not the minor, i.e., use medication for the main symptoms. The risk of kidney damage is increased by the interaction between various medications when too many medications are used. When faced with the situation of having to use drugs, you need to pay close attention to changes in kidney function. 2. Dehydration is the most direct cause of kidney damage. Severe diarrhea, vomiting, burns and other conditions that lead to a reduction in systemic volume, renal blood perfusion is also reduced, the kidneys themselves are already in a dangerous environment of ischemia and hypoxia, at this time, if exposed to nephrotoxic factors, more likely to cause acute kidney injury. When diuretics are used repeatedly for a long time in patients with kidney disease, the chances of kidney damage will be multiplied. 3, drugs are the most common factors of acute kidney injury in China. According to our professional literature, more than 40% of acute kidney injury is caused by drugs, leading to community-acquired acute kidney injury of the main drugs are: nephrotoxic drugs (39.2), non-steroidal anti-inflammatory drugs (8.7%), antibiotics (5.3%) and anti-cancer drugs (1.4%); leading to hospital-acquired acute kidney injury of the main drugs are: nephrotoxic drugs (42.9%), non-steroidal anti-inflammatory drugs (13.2%), contrast agents (9.1%), antibiotics (8.6%), and anticancer drugs (2.9%). Acute kidney injury is a medical problem and a social problem, and it is a problem that needs to be cared for by everyone. We suggest that all kidney disease patients strictly grasp the medication and check more often during the medication to prevent untoward.