The stomach is the “energy factory” of all the major tissues and organs of the body, and as the saying goes, “a bad stomach is the birth of a hundred diseases”. The reason why the stomach does not digest itself depends on the protection of the gastric mucosa, the tissue on the surface of the stomach wall. However, some drugs can stimulate damage to the gastric mucosa, leading to various acute and chronic gastritis. As the damage expands and deepens, gastric ulcers may also form, and the loss of gastric mucosa protection gastric acid can seep into our stomach to digest, and if the stomach is burned through, gastric perforation will form. Therefore, all kinds of gastric diseases start with the damage of gastric mucosa. So, which drugs can damage the gastric mucosa? Clinically, there are three types of common drugs that are more harmful to the gastric mucosa: first, anti-inflammatory and analgesic drugs, such as anti-inflammatory pain, ibuprofen, pau d’arco, etc.; second, antipyretic and analgesic drugs, such as aspirin, painkillers, paracetamol, etc.; third, adrenal corticosteroids, such as prednisone, dexamethasone, etc. If patients with chronic gastritis must take these drugs, they should communicate with their doctor to reduce the dose as much as possible, shorten the course of treatment or choose alternative drugs with less irritation, and it is best to take them after meals to reduce the irritation of the gastric mucosa. Some patients with gastric problems take strong analgesics such as morphine and prednisone because of sudden and severe stomach pain, which can quickly relieve pain but has a direct stimulating effect on the gastric mucosa and can easily form dependence. So try not to use them. In addition, some women who love beauty will take some, diet pills, detoxification drugs, estrogen drugs are also very damaging to the stomach. The State Drug Administration website can be found, with detoxification effect of the drug ingredients are basically Chinese medicine. Chinese medicine experts warn patients that medicine is three parts toxic, even detoxifying Chinese medicine, long-term use will also bring a series of toxic side effects, especially those that promote bowel movements, will make the intestinal reflex function, sensitivity is reduced, intestinal peristaltic force is weakened, digestive function is impaired, affecting the digestion and absorption of food, resulting in malnutrition and other consequences, the function of the gastrointestinal mucosa damage, need to be careful when taking. For patients suffering from chronic diseases that require frequent medication, it is best to take medication with some probiotic preparations, such as common Weilershu probiotics, Shuke Psi probiotics, etc., to help repair the damaged mucosal tissue and reduce the damage to the gastrointestinal mucosa from drug stimulation. In reality, most of the drugs we take orally are absorbed through the gastrointestinal system, so as long as people get sick, the gastrointestinal tract will inevitably be stimulated and damaged by certain drugs. According to clinical data, gastritis, gastrointestinal ulcers and bleeding caused by careless use of drugs account for more than one-third of the total number of gastric diseases, and the trend is increasing year by year.