Felty’s syndrome is also known as arthritis-granulocytopenia-splenomegaly syndrome, rheumatoid arthritis-splenomegaly syndrome, and infectious arthritis. It was first reported in 1924 in adults with chronic rheumatoid arthritis combined with granulocytopenia and splenomegaly, and has been repeatedly reported since then, so it is called Flety syndrome. Clinical manifestations The disease is a special type of rheumatoid arthritis, and the typical symptoms often appear after several months or even years of arthritis, and may include: 1. general malaise, fever, fatigue, anorexia, and emaciation. 2. 2. Brown pigmentation or even black pigmentation on the exposed skin. 3.Skin or mucous membrane ulcers, especially calf ulcers. 4.Spleen enlargement, some patients have giant spleen. 5. Some patients have enlarged lymph nodes, purple scarring and recurrent infections. Auxiliary examinations 1. Bone marrow: moderate hyperplasia of red blood cells per system, impaired granulocyte maturation. 2. Blood picture: moderate hypochromic anemia, mild reduction of platelets, significant reduction of neutrophils, which may be <1×109/L in severe cases; no significant change of lymphocytes. 3.Lupus erythematosus cytology was negative, Coomb's test was negative, and R-F latex agglutination test was often positive. Treatment 1. Application of steroid hormone therapy may have recent efficacy, but complete remission is rarely achieved. Anti-rheumatoid therapy, such as anti-inflammatory agents, penicillamine, zinc chloroquine sulfate, and rheumatism can be tried. Immunostimulants, the application of transfer factor, levamisole, etc. to stimulate cellular immune function has certain efficacy. Chinese herbal medicine treatment, Astragalus injection can regulate the immune function. 2, splenectomy, for severe granulocytopenia with severe anemia (hemolytic) or thrombocytopenia, recurrent infection is appropriate to perform splenectomy, but long-term remission only 30% to 40% of those.