In addition to the joints, rheumatoid arthritis can damage the heart, and lesions due to rheumatoid can occur in the heart, lungs, nerves, kidneys, eyes, and skin. Extra-articular manifestations of rheumatoid arthritis are signs of the severity of rheumatoid arthritis or the activity of the lesions, sometimes before the appearance of joint lesions, extra-articular systemic symptoms have been very prominent. Other systemic symptoms are mainly chronic interstitial pneumonitis (inflammation of the tissue between the alveoli), which can lead to emphysema and pulmonary fibrosis, and the most common symptoms are dyspnea and shortness of breath caused by static or activity. In addition, rheumatoid arthritis can develop old adhesive pericarditis, myocarditis, endocarditis and total carditis. If other systemic symptoms occur, the disease is more serious. The mortality rate of rheumatoid arthritis patients with visceral damage is about double that of those without extra-articular manifestations. The main causes of death in patients with rheumatoid arthritis are infections, cardiovascular and renal disease. In general, rheumatoid arthritis joint lesions are only disabling and rarely fatal.