There is no evidence of a role for chemotherapy in low-grade gliomas, except for those infantile patients with optic-crossing gliomas and midbrain gliomas who opt for chemotherapy because they cannot be treated with radiation. Based on the role of chemotherapy for genetically specific subtypes of oligodendrogliomas, where tumors with deletions of 1p and 19q are more sensitive to chemotherapy than tumors with intact 1p and 19q, there has been a renewed interest in chemotherapy for the treatment of low-grade oligodendrogliomas.