After removing the glioma and assisting certain radiotherapy, but still can’t stop the recurrence of the tumor, what should we do? The patient’s most worried thing still happened, don’t feel that the doctor didn’t cut the tumor cleanly, and don’t feel pessimistic and depressed, the most important thing is to think of a way to have a second treatment. There are many possibilities for tumor recurrence, some of them may be that the tumor itself has a high degree of malignancy, and it is easy to recur; some of them may be due to the fact that the original lesion involves an important functional area, and in order to avoid postoperative paralysis or aphasia, the doctor can not completely excise the tumor; and some of them may be that the patient does not pay attention to the “elimination of roots and branches” after the operation or is not sensitive to the chemotherapy drugs, resulting in the recurrence of the tumor. The patient may not pay attention to the post-surgery “chopping up the roots”, or may not be sensitive to the chemotherapy drugs, resulting in a recurrence. Although each of these situations is not optimistic, different treatments can be chosen according to the location, size and malignant degree of tumor recurrence, as well as the physical quality of the patient. If the tumor recurrence is more limited and not in the important brain function area, and the patient’s physical condition is more suitable for surgery, secondary surgical resection can be performed. If the patient’s liver and kidney functions are not good, especially in postoperative chemotherapy patients, and the liver and kidney functions and blood routine are not properly monitored, resulting in liver and kidney damage and poor blood coagulation, then the patient will not be able to withstand the second surgery after the recurrence occurs. If the patient’s tumor is very large or even grows to the opposite side of the brain, it is also not suitable for surgery. If the patient’s health is still relatively good at this time, partial resection of the tumor can be done, followed by chemotherapy and even radiotherapy to further stop the recurrent tumor cells from continuing to grow. Of course, if the patient doesn’t want to do surgery again, and if the patient’s physical condition is relatively good, liver and kidney functions are normal, and the economic condition allows, he/she can try to use the corresponding targeted drugs. Nowadays, there are almost no domestic targeted drugs, most of them are imported, so these drugs are very expensive. In foreign countries these targeted drugs can already be used to treat glioma, while in China the indications are mainly for lung cancer or other tumors. If a patient or family member requests the use of a targeted drug, they can consult with their doctor. For patients who are still undergoing chemotherapy, if there is a relapse, it means that the patient is not sensitive to the chemotherapy drugs, at this time it is not recommended to increase the dosage of chemotherapy drugs, but should be directly changed to other more sensitive drugs, or even replace the whole chemotherapy program.