Gliomas are the most common primary cranial tumors arising from malignant transformation of brain glial cells. The annual incidence is about 3-8 per 100,000 population. For some low-grade gliomas, complete surgical resection can lead to radical treatment and long-term survival. However, for high-grade gliomas, due to unclear boundary, irregular shape, large size and invasion of functional brain area, complete surgical resection is very difficult, and the recurrence rate is very high after surgery, and there is a lack of effective methods for the recurrence of gliomas after surgery. In recent years, the development of iodine 125 radioactive particle implantation for the treatment of malignant tumors has provided a very effective method for high-grade gliomas, especially those that cannot be surgically resected, those that remain after surgical resection, or those that recur after surgery. Our department uses the best MRI for cranial imaging as an image-guiding device, and under the design of the Tumor Planning System (TPS), radioactive particles are uniformly implanted into tumors, so that they can be used internally for long-term, continuous radiation therapy of tumors, with good results. Advantages of magnetic resonance-guided iodine 125 radioactive particle therapy for malignant glioma: 1, high local radiation dose, higher than several times of external radiotherapy, better and more accurate therapeutic effect; 2, the dose of iodine 125 radioactive particles attenuates rapidly with the increase of the radius of action, which is less damaging to normal brain tissues around the lesion, and seldom causes the body disorder caused by the damage of brain functional area; 3, carried out under local anesthesia, with small trauma and good reproducibility. It is especially suitable for patients with high-grade gliomas that cannot be surgically resected, remain after surgical resection and recur after surgical resection; 4. Magnetic resonance, the best choice for cranial brain imaging, is used as the intraoperative guiding and monitoring imaging modality, which is able to clearly limit the boundaries of the lesion and ensure the accuracy, safety and reasonable distribution of radioactive particles for intraoperative puncture; 5. 5. Radioactive particle implantation can be used in combination with various methods to achieve better results, such as: combined with surgery for residual lesions that cannot be completely removed by surgery; combined with chemotherapy such as temozolomide, avastin and other targeted therapies to improve the therapeutic efficacy.