To determine whether it is gout or not, it is necessary to combine the patient’s clinical manifestations, such as redness, swelling and heat pain in the joints, etc.; laboratory tests, such as blood uric acid, blood sedimentation, C-reactive protein, etc.; and imaging tests, such as joint ultrasound, X-ray, CT, etc. for comprehensive analysis and judgment. Gout is a heterogeneous group of diseases caused by purine metabolism disorders and (or) uric acid excretion disorders, and its clinical features are elevated serum uric acid, recurrent acute arthritis, gouty stones and joint deformities, uric acid renal calculi, glomerular, tubular, interstitial, and vascular renal lesions. 1. Clinical manifestations: presence of swelling, pain, or tenderness in at least one peripheral joint or bursa; polarized light microscopy confirms the presence of sodium urate crystals in (previously) symptomatic joints or bursae or gouty stones. There is clinical evidence of gouty stone: subcutaneous grayish-white nodules with thin surface skin and rich blood supply; chalk-chip-like urate crystals can be discharged outward when the skin breaks down. 2. Laboratory examination: blood uric acid level, C-reactive protein increase, blood sedimentation increase. 3. Imaging examination: joint ultrasound has “double track sign”; dual-energy CT has urate deposits; X-ray shows at least one bone erosion in the hand and/or foot. The combination of these signs allows the doctor to make a definitive diagnosis. If the diagnosis of gout is confirmed, it is recommended to cooperate with the doctor as soon as possible to standardize the diagnosis and treatment in order to effectively control the disease.