Both antipyretic suppositories and ibuprofen are antipyretic and analgesic drugs, antipyretic suppositories are topical drugs and ibuprofen is an oral preparation, and there are individual differences in the efficacy of the two, each with its own advantages and disadvantages. Fever Relief Suppositories and Ibuprofen can be used for fever caused by the common cold or influenza, and are also used for the relief of mild to moderate pain such as headache, arthralgia, migraine, toothache, muscular pain, and neuralgia. Fever-reducing suppositories are topical medications, administered rectally, and are more suitable for patients who are not suitable for oral medication; ibuprofen is mainly an oral preparation, which is convenient and suitable for the majority of the population. Both are antipyretic and analgesic, can not be used for severe hepatic and renal insufficiency, can not be taken at the same time other drugs containing antipyretic and analgesic, allergy is prohibited, allergy with caution; ibuprofen oral may appear nausea, vomiting, induced peptic ulcers and other adverse reactions; antipyretic suppositories may appear rash, urticaria, drug fever and granulocytopenia and other adverse reactions. Antipyretic suppositories and ibuprofen have their own advantages and disadvantages, should be selected in conjunction with the patient’s condition, and used under the guidance of a physician.