Puffy upper eyelids may be caused by elevated local vascular permeability, decreased albumin in the blood, and sodium retention. 1. Elevated local vascular permeability: it may be caused by infection, allergy and trauma. Local inflammation will lead to elevated vascular permeability, and a large amount of plasma in the blood vessels will leak into the tissues, causing swelling of the upper eyelids. 2. Decreased albumin in the blood: it may be caused by nephrotic syndrome, nephritis and other reasons. A large amount of albumin in the blood will be excreted through the urine, the concentration of albumin in the blood decreases, and the liquid will flow to the interstitial space of the tissues with high protein concentration, which can cause swelling of the upper eyelid. 3. Sodium retention: the most common cause is excessive salt intake, the body’s sodium salt more than the body needs the content of the body, easy to cause an increase in the amount of blood vessel content, excessive water aggregation caused by the upper eyelid edema, increased blood pressure and other phenomena. In addition, excessive water consumption before bedtime and other physiological reasons may also cause upper eyelid edema, but usually lasts for a short period of time. If upper eyelid edema exists for a long time, it is recommended to go to the hospital in time and follow the doctor’s instructions for treatment to avoid delaying the condition.