Pulmonary blisters are not a clinical disease but a structural change, which is caused by the destruction of the alveolar wall, resulting in the fusion of adjacent alveoli into a relatively large cystic cavity, which loses its normal lung function and structure and is therefore not able to exchange gas effectively. If the diameter of the alveoli is small, they do not affect the body, do not cause clinical symptoms, and do not require treatment. In the case of large pulmonary blisters, they can be complicated by infection causing cough and sputum, and can be treated with cough suppressant and expectorant medications and given anti-infective treatment. In the case of large pulmonary blisters with risk of rupture and spontaneous pneumothorax, active surgical removal is required.