The common causes of lip numbness are as follows: 1, neuropathy innervating the oral perilabial area: common in peripheral neuritis, central neuropathy, such as major diseases, can be accompanied by other symptoms of nerve damage; 2, chemical and biological stimulation: eating special foods such as mangoes, causing changes in oral perilabial mucous membrane cells and muscle cells, which can be recovered in the short term; 3, psychogenic factors: that is, psychological effects, excessive concern, manifested as perilabial numbness; 4, oral inflammation: such as mycotic infection, bacterial infection, can cause perilabial numbness.