Vomiting in the middle of the night needs to consider the following aspects: first, due to eating too much, eating improperly, eating unclean things, may lead to acute gastroenteritis, when the stomach peristalsis is more obvious, easy to cause vomiting. Secondly, it is considered that the cardia is flaccid, which is seen in children and the elderly, children are too young and their development is not particularly mature, and the cardia is more flaccid, and the elderly are flaccid due to the reduction of muscle strength or long-term cardia disease esophageal disease. Third, due to reflex vomiting, mainly due to brain lesions, commonly have increased cranial pressure, brain tumors such as occupation easily cause intracranial pressure increase. Fourth, visible pregnant women vomiting during pregnancy, estrogen levels rise during pregnancy, the body’s neurohumoral regulation is different from normal people, for the flavor is more sensitive to be easily stimulated and cause vomiting.