Gout itself does not usually affect fertility. However, medications used to treat gout such as colchicine have teratogenic effects that may affect fertility. Gout is a common metabolic disease, mostly related to lifestyle, diet, and genetics. It is usually caused by a disorder of purine metabolism in the body, leading to a gradual increase in blood uric acid level, which accumulates in the body and precipitates around the joints, and then triggers some inflammatory manifestations of joint pain. This disease is generally not closely related to the reproductive system, will not directly lead to infertility, and will not affect the sperm production as well as egg development. However, drugs used to treat gout such as colchicine have teratogenic effects that may affect fertility. It should be noted that patients with gout need to stop or reduce the use of some medications during the preparation for pregnancy to avoid affecting the fetus. It is recommended that gout patients go to the rheumatology and immunology department of the regular hospital, under the guidance of the doctor to choose the medication, do not self-medication.