The serious side effects of cisplatin are mainly reflected in the digestive system, hematopoietic system, nervous system, urinary system and other aspects. 1. Digestive system: mainly manifested as nausea, vomiting, decreased appetite, etc., often occurring within 6 hours after the administration of the drug, usually not more than two days. 2. Hematopoietic system: it can lead to the reduction of white blood cells and platelets, and the bone marrow suppression can reach the peak in about 3 weeks, and usually recover in 4~6 weeks. 3. Nervous system: peripheral nerve injury is common, which can be manifested as myalgia, motor disorders, sensory abnormalities in upper and lower limbs, and so on. 4. Urinary system: cisplatin has nephrotoxicity, may appear slight renal impairment, such as large dose or short-term frequent administration may even appear renal tubular necrosis, resulting in anuria or uremia. 5. Allergic reactions: such as accelerated heart rate, lowered blood pressure, facial edema, allergic fever reaction. 6. Others: tinnitus, hyperuricemia, cardiac arrhythmia, immunosuppression and other side effects may occur. The use of cisplatin should be under the guidance of a physician, if a more serious adverse reaction occurs, you should consult a doctor in a timely manner, if necessary, stop the drug immediately.