The development of modern technology has enabled clinicians to make increasingly accurate diagnoses. Compared to a decade or decades ago, many diseases can be diagnosed at the early stage of onset, and can also help determine the efficacy, regression and the presence of recurrence. The increasing number of tests has also contributed to the improvement of physicians’ standards. However, the abundance of tests has increased the cost of disease and complicated the determination of disease, while making physicians overly dependent on these tests. Probably many people have the same experience. Nowadays, when I go to the hospital myself, doctors no longer look, smell, and treat, but after a simple inquiry and routine physical examination, they order tests and prescribe medication. It is true that the doctor’s physical examination and empirical judgment are not as direct and objective as the means of examination. But the doctor is not only treating the disease, but is first and foremost the patient. A mere examination cannot appreciate the subtle physical experience and changes of the patient. Sometimes some disputes arise from the neglect of the patient’s illness. The examination may also overdiagnose the disease. A more typical example is neonatal hypoxic-ischemic encephalopathy. The diagnostic criteria for this disease are a history of perinatal asphyxia, including a ph less than 7.1, a five-minute Apgar score less than 5, a BE less than -15, neurological symptoms, and manifestations of multi-organ damage. The grading is also based on the clinical presentation, including the infant’s response, muscle tone, and the presence or absence of convulsions. However, many places perform cranial imaging on neonates with asphyxia and diagnose hypoxic-ischemic encephalopathy based on what is seen on imaging, when the infant has no neurological symptoms at all. An overdiagnosis often predicts overtreatment. There are other examples, such as the most common blood tests, which can be performed many items at once for a low fee (about $10 per test) because they are performed by machine. However, the sensitivity and specificity of many tests are not high, especially for some routine laboratory tests, and a simple analysis of the laboratory report, in isolation from the patient’s presentation, can lead to many different interpretations. How to solve this problem? It is impossible to solve it if you want the doctor to know where the disease is at a glance. It takes time for each person to think about a problem, let alone one related to a complex body, so the doctor needs detailed questioning and physical examination, as well as multiple iterations of judgment and back-and-forth comparisons, and even collaboration among multiple doctors or disciplines, before the accuracy of the judgment can be increased. Of course, the patient needs to be patient and to be able to forgive the doctor for the temporary lapse in judgment.