The actual fact is that you will be able to have children with ankylosing spondylitis as an autoimmune disease, but it is not advisable to have children while taking medication, especially immunosuppressant treatment, because some drugs, especially methotrexate, meloxicam, lorazepam and other drugs can lead to miscarriage, fetal malformation and stillbirth after pregnancy, which can have an effect on the fetus, and it is recommended to stop taking medication for more than six months before considering pregnancy. If the spinal joint is affected by severe spinal iliac sacral joint, some have an impact on the heart, kidneys and nervous system, so it is important to go to a regular hospital and get pregnant after a thorough evaluation by a doctor, mainly considering the physical condition or the impact on the fetus after pregnancy.