Prickly heat in infants and toddlers needs to be treated firstly by cooling and drying the skin, and then by using cool and itch-relieving lotion, and antibiotics need to be combined with those who have infections. Infant prickly heat is a superficial, inflammatory skin disease commonly seen in summer or hot environments. Infants and young children with underdeveloped sweat ducts are more prone to prickly heat. Thus, when prickly heat occurs in infants and young children, the first thing to do is to cool and dry the skin, such as using wet cloths to apply cold compresses, ventilating the room, and wearing loose clothing. It can also be treated with cool and itch-relieving lotions such as glycerite lotion under the guidance of medical professionals, and if combined with bacterial infection, mupirocin ointment should be applied topically. In addition, parents should also pay attention to avoid infants and young children scratching the skin lesions to cause or aggravate the infection.