Atorvastatin can be taken at any time of the day and is not affected by meals; there is no best time to take the drug. Statins are commonly used clinically as lipid-lowering drugs for conditions such as hypercholesterolemia and coronary heart disease. Atorvastatin is a long-acting statin and the reduction in LDL-C is the same regardless of the time of day it is given. Therefore, there is no best time to give the drug; it can be taken at any time of the day and is not affected by meal intake. Adverse reactions are rhabdomyolysis and liver enzyme abnormalities with atorvastatin; precautions are that co-administration of this drug with fusidic acid is not recommended, and caution should be exercised with colchicine. Liver function should be reviewed periodically and used with caution in patients with excessive alcohol consumption and/or a history of fatty liver. Contraindications to the use of this drug are active liver disease, hypersensitivity to the components of this drug, pregnancy and lactation. Atorvastatin should be used in strict accordance with the doctor’s instructions, regular reviews, and in case of discomfort, prompt medical attention.