The common clinical causes of axillary pain in female patients are mainly the following: First, the patient’s axilla is accompanied by superficial mass growth, such as lipomas, fibroids and other benign lesions, and with the gradual increase in the volume of the mass, the patient’s axilla will be accompanied by obvious pain as the tension increases significantly. At this time, it is recommended that the patient improve the ultrasound examination to clarify the size and scope of the mass, and perform the removal of the mass as soon as possible so as to reduce the painful symptoms in the armpit. Second, female patients in the fitness exercise because of their own muscle tension is weak, if the fitness amplitude is larger, longer will cause muscle strain in the armpit, accompanied by pain. At this time, patients need to take sufficient rest, and appropriate massage, physical therapy, infrared irradiation, local hot compresses at the strained muscles can promote faster recovery of injured tissues, thus alleviating the pain and discomfort in the armpits.