How to treat neuropathic pain in diabetic patients?

  Diabetic neuropathic pain, also known as painful diabetic peripheral neuropathy, is a type of neuropathic pain (neuralgia). The disease is mostly a terminal sensory polyneuropathy, with motor deficits at the end often mild and sensory deficits generally symmetrical, starting in the toes and progressing to the feet as well as the lower legs as the disease progresses, with the upper extremities generally being involved later. The upper extremities are usually affected later. There is a typical short sock and glove sensory deficit. The trunk may also be involved in later stages. If the involvement is predominantly of small fibers, there is often varying degrees of pain and sensory disturbance. The nature of the pain can be varied, such as burning pain, twisting pain, pins and needles, and flashing pain. There may be tactile abnormalities in the skin and temperature abnormalities, such as a cold sensation or fever. Acute painful neuropathy is thought to be a separate syndrome. The incidence is low, but it is very uncomfortable. This condition is seen in diabetic patients with poor glycemic control. It is often associated with significant weight loss, with severe persistent burning-like pain and swelling of the foot sensation. It tends to be heaviest on the soles of the feet and can also involve the entire lower extremity, occasionally including the hands. In addition to persistent burning pain, there may be intermittent searing stabbing pain radiating upward from the foot to the calf, more intense at night. The skin may also have abnormal sensation. There is also a condition called treatment-induced neuropathy, where a small number of patients develop sensory neuropathy when they start treatment with insulin, which is called “insulin neuropathy” and manifests as terminal sensory abnormalities and even pain, mainly in the lower limbs. It is thought that these cases may have had insidious neuropathy and insulin treatment improved the hyperglycemic environment and the axons began to regenerate. The abnormal impulses that occur in these new nerve fibers lead to abnormal sensation.  In summary, the causes of this disease invariably stem from uncontrolled diabetes, and in some cases, further examination of the nerve pain leads to the discovery that you have diabetes. Diabetic peripheral neuralgia is not only painful, but also often leads to insomnia, depression, and anxiety. In severe cases, it can affect the ability to work and live, leading to reduced or even lost social functioning. And the current general treatment of the disease from the following aspects. The first is to treat the primary disease, that is, to control diabetes and blood glucose to achieve the treatment goal. Secondly, nerve-nourishing drugs such as Group B vitamins can be used. Thirdly, appropriate analgesic drugs are chosen to relieve the pain caused by the pain. Traditional analgesic medication is ineffective, and several international guidelines recommend the use of antidepressant and anticonvulsant medications, and also the use of therapeutic measures such as acupuncture or topical medication. Studies have shown that only 22% to 42% of patients are satisfied with the treatment. In view of the high incidence and serious consequences of neuropathic pain, the latest international treatment philosophy currently emphasizes early diagnosis and early treatment to reduce diagnosis time and save time and cost. In addition, because of the diverse manifestations of neuropathic pain and the variable complaints of patients at the time of consultation, standardized treatment procedures that are consistent with domestic clinical experience and circumstances need to be developed. However, as seen in the current data on neuropathic pain, the diagnosis of diabetic peripheral neuralgia is often made in the middle and late stages. In fact, the diagnosis of the disease is not difficult, and there are well-established international diagnostic criteria. It is recommended that the corresponding patients promptly visit the neurology and endocrinology departments to relieve the pain as early as possible.  In the case of less than ideal treatment effect, good foot care for diabetic patients is an effective means to prevent and treat diabetic neuropathic pain.  Specific foot care methods are the following five: 1, warm water to wash feet, dry between the toes – daily wash feet with warm water and neutral soap, do not wash feet when the water temperature is too high to avoid burns. Your feet may not feel the heat of the water, so try it with your hands first. Remember not to soak for too long, as sores that have been soaked in water are more difficult to heal. Dry your feet immediately after washing them, paying attention to the toe seam, and remember to gently dry all the areas between the toes.  2. Cut your toenails regularly and moisturize your skin – High blood sugar levels can cause your skin to dry out and crack. Cracked skin means bacteria are more likely to grow under the skin, making it more difficult to heal after an infection. Apply a small amount of lotion daily to ensure your feet are dry (not wet or sticky), but don’t get the lotion in the area between your toes. You will find it easy to trim your toenails after using the lotion because the lotion softens your epidermis. Cut your toenails short, but not too short, and gently smooth the edges. Do not feel free to dig the corns and calluses on your feet to prevent skin infections.  3. Proper shoes, breathable socks – Even the slightest friction or ill-fitting shoes can trigger edema and then start an infection that can turn into a badly treated ulcer. Before buying shoes or trying them on, examine the pair carefully to see if there are any rough seams, sharp edges or other things that can hurt your feet. Wear socks when wearing shoes, because leather, plastic and man-made shoes are made of materials that can irritate the skin and quickly trigger edema, which can be caused by wearing thicker socks. So it is best to wear well-fitting clean and soft shoes and breathable thread socks.  4, appropriate exercise, reasonable massage – swimming, cycling, yoga and Tai Chi are very popular sports, and will not have a great impact on your feet. Some years ago it was popular to walk barefoot on cobblestones, which is indeed helpful from the perspective of foot massage, but not suitable for diabetics and often aggravates foot symptoms, so ask your doctor before you start your exercise program. Both can promote smooth blood circulation, unblock the body’s energy circulation pipeline, and promote the normal function of organs and coordination between organs and systems, and are now receiving more and more attention from the medical community. Chinese herbal foot bath for diabetic patients, need to be carried out under the guidance of a doctor, the medicine with cinnamon stick, horsetail, safflower, atractylodes, Poria, Phellodendron, Paeonia, bitter ginseng, Mao Dongqing, Lonicera, etc. decoction, to be warm soak the affected foot, the same need to pay attention to the temperature of the liquid, to prevent burns.  5, control blood sugar, the top priority – Finally, the best treatment and prevention for neuralgia is to deal with your diabetes. In fact, a study done by the American Diabetes Association in 2006 showed that controlling blood sugar with intensive insulin therapy reduced the likelihood of peripheral neuropathy by 64%. While you can’t control the development of diabetic peripheral neuropathy or not, you can by controlling your diet and increasing your exercise. Eat foods that are low in sugar, high in protein, high in fiber, and moderate in fat. Avoid sweets and eat little or no high-calorie, high-cholesterol, low-vitamin, low-mineral and fried foods. Eat more fresh vegetables and algae, increase the intake of coarse grains and improve the content of fiber in the diet, such as corn, millet, oatmeal, whole wheat flour, buckwheat and soy flour foods. Moderate exercise can control weight and improve the overall quality of the patient’s body. Patients should choose the right type of exercise for themselves, step by step, persistent. You can also use medical treatment if needed to control your blood sugar concentration.  In conclusion, to get rid of diabetic peripheral neuralgia, diabetic patients must control the cause, lower blood sugar, prevention-oriented, early detection and timely treatment.