Hepatitis may cause splenomegaly and widening of the splenic portal vein, but there are other conditions such as infectious diseases, immune disorders, and hematologic disorders that can also cause splenomegaly. The details are as follows: 1. Hepatitis: Acute hepatitis usually does not cause splenomegaly. Chronic hepatitis patients such as portal hypertension can lead to splenomegaly, increased obstruction of splenic venous reflux and retrograde transmission of portal venous pressure to the spleen, so that the spleen passive bruising enlargement, splenic tissue hyperplasia, causing splenomegaly and splenic portal vein widening. 2. Infectious diseases: e.g. schistosomiasis, malaria, tuberculosis of cornual type. Advanced cirrhosis of schistosomiasis causes portal hypertension, splenic stasis, thrombosis, etc., which leads to progressive enlargement of the spleen, which may result in giant spleen and hypersplenism. 3. Immune diseases: Felty’s syndrome of rheumatoid arthritis, systemic lupus erythematosus (the blood system is involved, which can lead to hemolytic anemia and then secondary splenomegaly), etc. 4. Blood system diseases: autoimmune hemolytic anemia, thalassemia, acute and chronic leukemia. There may be other reasons for splenomegaly and splenic portal vein widening, so it is recommended to consult a doctor in time for targeted treatment under the doctor’s guidance. Please do not take medication on your own to avoid delaying your condition.